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. 2001 Mar 15;166(6):3655-8.
doi: 10.4049/jimmunol.166.6.3655.

VSports在线直播 - Cutting edge: human gamma delta T cells are activated by intermediates of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis

B Altincicek  1 , J Moll, N Campos, G Foerster, E Beck, J F Hoeffler, C Grosdemange-Billiard, M Rodríguez-Concepción, M Rohmer, A Boronat, M Eberl, H Jomaa
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Cutting edge: human gamma delta T cells are activated by intermediates of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis

B Altincicek et al. J Immunol. .

Abstract (VSports注册入口)

Activation of V gamma 9/V delta 2 T cells by small nonprotein Ags is frequently observed after infection with various viruses, bacteria, and eukaryotic parasites. We suggested earlier that compounds synthesized by the 2-C:-methyl-D-erythritol 4-phosphate (MEP) pathway of isopentenyl pyrophosphate synthesis are responsible for the V gamma 9/V delta 2 T cell reactivity of many pathogens. Using genetically engineered Escherichia coli knockout strains, we now demonstrate that the ability of E. coli extracts to stimulate gamma delta T cell proliferation is abrogated when genes coding for essential enzymes of the MEP pathway, dxr or gcpE, are disrupted or deleted from the bacterial genome VSports手机版. .

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