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. 2000 Dec;28(3):665-79.
doi: 10.1016/s0896-6273(00)00145-8.

LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome

Y Feng  1 , E C Olson, P T Stukenberg, L A Flanagan, M W Kirschner, C A Walsh
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LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome

V体育安卓版 - Y Feng et al. Neuron. 2000 Dec.
Free article

VSports最新版本 - Abstract

LIS1, a microtubule-associated protein, is required for neuronal migration, but the precise mechanism of LIS1 function is unknown. We identified a LIS1 interacting protein encoded by a mouse homolog of NUDE, a nuclear distribution gene in A. nidulans and a multicopy suppressor of the LIS1 homolog, NUDF VSports手机版. mNudE is located in the centrosome or microtubule organizing center (MTOC), and interacts with six different centrosomal proteins. Overexpression of mNudE dissociates gamma-tubulin from the centrosome and disrupts microtubule organization. Missense mutations that disrupt LIS1 function block LIS1-mNudE binding. Moreover, misexpression of the LIS1 binding domain of mNudE in Xenopus embryos disrupts the architecture and lamination of the CNS. Thus, LIS1-mNudE interactions may regulate neuronal migration through dynamic reorganization of the MTOC. .

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