Background: The relative effectiveness of various antihypertensive drugs with regard to the reduction of stroke incidence remains uncertain. VSports手机版.

Objective: To assess the association between first ischemic stroke and use of antihypertensive drugs. V体育安卓版.

Methods: A population-based case-control study was performed among enrollees of the Group Health Cooperative of Puget Sound. Case patients included pharmacologically treated hypertensive patients who sustained a first ischemic stroke (fatal or nonfatal; n = 380) between July 1, 1989, and December 31, 1996. Control subjects were a random sample of treated hypertensive enrollees without a history of a stroke (n = 2790). Medical record review and a telephone interview of consenting survivors were used to collect information on risk factors for stroke. Computerized pharmacy records were used to assess antihypertensive drug use V体育ios版. .

Results: Among 1237 single-drug users with no history of cardiovascular disease, the adjusted risk of ischemic stroke was higher among users of a beta-blocker (risk ratio [RR], 2. 03; 95% confidence interval [CI], 1. 05-3. 94), calcium channel blocker (RR, 2. 30; 95% CI, 1. 16-4. 56), or angiotensin-converting enzyme inhibitor (RR, 2. 79; 95% CI, 1. 47-5. 27) than among users of a thiazide diuretic alone. Among 673 single-drug users with a history of cardiovascular disease, the RRs were 1. 22 (95% CI, 0. 63-2. 35), 1. 18 (95% CI, 0. 59-2. 33), and 1. 45 (95% CI, 0. 70-3 VSports最新版本. 02) among users of a beta-blocker, calcium channel blocker, and angiotensin-converting enzyme inhibitor, respectively, compared with users of a thiazide diuretic alone. .

Conclusions: In this study of pharmacologically treated hypertensive patients, antihypertensive drug regimens that did not include a thiazide diuretic were associated with an increased risk of ischemic stroke compared with regimens that did include a thiazide. These results support the use of thiazide diuretics as first-line antihypertensive agents. V体育平台登录.