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. 2000 Nov;1(5):426-32.
doi: 10.1038/80868.

Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

K S Schluns  1 , W C Kieper, S C Jameson, L Lefrançois
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Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

K S Schluns et al. Nat Immunol. 2000 Nov.

Abstract

The naïve and memory T lymphocyte pools are maintained through poorly understood homeostatic mechanisms that may include signaling via cytokine receptors VSports手机版. We show that interleukin-7 (IL-7) plays multiple roles in regulating homeostasis of CD8+ T cells. We found that IL-7 was required for homeostatic expansion of naïve CD8+ and CD4+ T cells in lymphopenic hosts and for CD8+ T cell survival in normal hosts. In contrast, IL-7 was not necessary for growth of CD8+ T cells in response to a virus infection but was critical for generating T cell memory. Up-regulation of Bcl-2 in the absence of IL-7 signaling was impaired after activation in vivo. Homeostatic proliferation of memory cells was also partially dependent on IL-7. These results point to IL-7 as a pivotal cytokine in T cell homeostasis. .

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