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. 2000 Sep 15;102(6):827-37.
doi: 10.1016/s0092-8674(00)00071-4.

V体育安卓版 - The polymeric immunoglobulin receptor translocates pneumococci across human nasopharyngeal epithelial cells

J R Zhang  1 , K E Mostov, M E Lamm, M Nanno, S Shimida, M Ohwaki, E Tuomanen
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VSports手机版 - The polymeric immunoglobulin receptor translocates pneumococci across human nasopharyngeal epithelial cells

J R Zhang (VSports最新版本) et al. Cell. .
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"V体育安卓版" Abstract

The polymeric immunoglobulin receptor (pIgR) plays a crucial role in mucosal immunity against microbial infection by transporting polymeric immunoglobulins (pIg) across the mucosal epithelium. We report here that the human pIgR (hpIgR) can bind to a major pneumococcal adhesin, CbpA. Expression of hpIgR in human nasopharyngeal cells and MDCK cells greatly enhanced pneumococcal adherence and invasion. The hpIgR-mediated bacterial adherence and invasion were abolished by either insertional knockout of cbpA or antibodies against either hpIgR or CbpA VSports手机版. In contrast, rabbit pIgR (rpIgR) did not bind to CbpA and its expression in MDCK cells did not enhance pneumococcal adherence and invasion. These results suggest that pneumococci are a novel example of a pathogen co-opting the pIg transcytosis machinery to promote translocation across a mucosal barrier. .

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