Background: Oncogene amplification and chromosomal anomalies are found in many solid tumors and are often associated with aggressiveness of cancer. We evaluated the frequency and the association of c-myc and androgen receptor (AR) gene amplification and gain of chromosome 8 or X in prostate cancer in Japanese patients VSports手机版. .

Methods: We examined a total of 42 prostate cancer specimens, using fluorescence in situ hybridization (FISH). Dual-labeling hybridization with a directly labeled centromere probe for chromosome 8 or X together with a probe for the c-myc or AR locus was performed. V体育安卓版.

Results: Gain of chromosome 8 was identified in 54. 8% of specimens and was associated with Gleason sum and nuclear anaplasia in untreated prostate cancers V体育ios版. c-myc gene amplification was found in 14. 3% of specimens. Gain of chromosome X was identified in 42. 9% of specimens. AR gene amplification was detected in 0 of 37 untreated prostate cancers, but in 1 of 5 hormone-refractory prostate cancers. .

Conclusions: Our results suggest that c-myc and AR gene amplification and gain of chromosome 8 or X may be associated with the development and progression of prostate cancers VSports最新版本. These results obtained in Japanese cases are consistent with the results observed in prostate cancer in Western countries. .