Background: A recent review suggested an association between using unpublished scales in clinical trials and finding significant results VSports手机版. .

Aims: To determine whether such an association existed in schizophrenia trials. V体育安卓版.

Method: Three hundred trials were randomly selected from the Cochrane Schizophrenia Group's Register. All comparisons between treatment groups and control groups using rating scales were identified. The publication status of each scale was determined and claims of a significant treatment effect were recorded V体育ios版. .

Results: Trials were more likely to report that a treatment was superior to control when an unpublished scale was used to make the comparison (relative risk 1. 37 (95% CI 1. 12-1. 68)). This effect increased when a 'gold-standard' definition of treatment superiority was applied (RR 1. 94 (95% CI 1 VSports最新版本. 35-2. 79)). In non-pharmacological trials, one-third of 'gold-standard' claims of treatment superiority would not have been made if published scales had been used. .

Conclusions: Unpublished scales are a source of bias in schizophrenia trials. V体育平台登录.