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. 1999 Nov;31(4):901-16.
doi: 10.1081/dmr-100101945.

Trichloroethylene activates CD4+ T cells: potential role in an autoimmune response

K M Gilbert  1 , J M Griffin, N R Pumford
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Trichloroethylene activates CD4+ T cells: potential role in an autoimmune response

K M Gilbert et al. Drug Metab Rev. 1999 Nov.

Abstract

Trichloroethylene is an industrial solvent and has become a major environmental contaminant. Autoimmune-prone MRL +/+ mice were treated for up to 22 weeks with trichloroethylene in the drinking water (0, 2. 5, and 5. 0 mg/mL) in order to study the immunoregulatory effects of this environmental toxicant. After only 4 weeks of treatment, trichloroethylene was shown to promote the expansion of CD4+ T cells that expressed a memory/activation phenotype (i. e. , CD44hi CD45RBlo) and secreted high levels of IFN-gamma, but not IL-4. In addition, trichloroethylene treatment accelerated the development of an autoimmune response in the MRL +/+ mice as evidenced by an earlier appearance of antinuclear antibodies and increased levels of total IgG2a. MRL +/+ mice treated with trichloroethylene for 22 weeks also contained antibodies specific for trichloroethylene adducts, suggesting the activation of trichloroethylene-specific T cells. The results suggest that trichloroethylene can stimulate antigen nonspecific as well as specific T cells that are capable of promoting autoimmunity in genetically predisposed individuals VSports手机版. .

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