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. 1999 Nov 19;286(5444):1561-5.
doi: 10.1126/science.286.5444.1561.

Specific lipopolysaccharide found in cystic fibrosis airway Pseudomonas aeruginosa

R K Ernst  1 , E C Yi, L Guo, K B Lim, J L Burns, M Hackett, S I Miller
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VSports注册入口 - Specific lipopolysaccharide found in cystic fibrosis airway Pseudomonas aeruginosa

R K Ernst (V体育官网入口) et al. Science. .

V体育平台登录 - Abstract

Cystic fibrosis (CF) patients develop chronic airway infections with Pseudomonas aeruginosa (PA) VSports手机版. Pseudomonas aeruginosa synthesized lipopolysaccharide (LPS) with a variety of penta- and hexa-acylated lipid A structures under different environmental conditions. CF patient PA synthesized LPS with specific lipid A structures indicating unique recognition of the CF airway environment. CF-specific lipid A forms containing palmitate and aminoarabinose were associated with resistance to cationic antimicrobial peptides and increased inflammatory responses, indicating that they are likely to be involved in airway disease. .

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