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. 1999 Jul 16;285(5426):412-5.
doi: 10.1126/science.285.5426.412.

Prevention of graft versus host disease by inactivation of host antigen-presenting cells

W D Shlomchik  1 , M S Couzens, C B Tang, J McNiff, M E Robert, J Liu, M J Shlomchik, S G Emerson
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Prevention of graft versus host disease by inactivation of host antigen-presenting cells

W D Shlomchik et al. Science. .

Abstract

Graft versus host disease, an alloimmune attack on host tissues mounted by donor T cells, is the most important toxicity of allogeneic bone marrow transplantation VSports手机版. The mechanism by which allogeneic T cells are initially stimulated is unknown. In a murine allogeneic bone marrow transplantation model it was found that, despite the presence of numerous donor antigen-presenting cells, only host-derived antigen-presenting cells initiated graft versus host disease. Thus, strategies for preventing graft versus host disease could be developed that are based on inactivating host antigen-presenting cells. Such strategies could expand the safety and application of allogeneic bone marrow transplantation in treatment of common genetic and neoplastic diseases. .

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