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. 1999 Jun 18;284(5422):1994-8.
doi: 10.1126/science.284.5422.1994.

"VSports注册入口" Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF

J Holash  1 , P C Maisonpierre, D Compton, P Boland, C R Alexander, D Zagzag, G D Yancopoulos, S J Wiegand
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Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF

"VSports注册入口" J Holash et al. Science. .

Abstract

In contrast with the prevailing view that most tumors and metastases begin as avascular masses, evidence is presented here that a subset of tumors instead initially grows by coopting existing host vessels VSports手机版. This coopted host vasculature does not immediately undergo angiogenesis to support the tumor but instead regresses, leading to a secondarily avascular tumor and massive tumor cell loss. Ultimately, however, the remaining tumor is rescued by robust angiogenesis at the tumor margin. The expression patterns of the angiogenic antagonist angiopoietin-2 and of pro-angiogenic vascular endothelial growth factor (VEGF) suggest that these proteins may be critical regulators of this balance between vascular regression and growth. .

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