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. 1999 Feb;3(2):247-53.
doi: 10.1016/s1097-2765(00)80315-9.

Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits

M L Phelan  1 , S Sif, G J Narlikar, R E Kingston
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VSports在线直播 - Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits

"V体育2025版" M L Phelan et al. Mol Cell. 1999 Feb.
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Abstract

Protein complexes of the SWI/SNF family remodel nucleosome structure in an ATP-dependent manner. Each complex contains between 8 and 15 subunits, several of which are highly conserved between yeast, Drosophila, and humans. We have reconstituted an ATP-dependent chromatin remodeling complex using a subset of conserved subunits. Unexpectedly, both BRG1 and hBRM, the ATPase subunits of human SWI/SNF complexes, are capable of remodeling mono-nucleosomes and nucleosomal arrays as purified proteins. The addition of INI1, BAF155, and BAF170 to BRG1 increases remodeling activity to a level comparable to that of the whole hSWI/SNF complex. These data define the functional core of the hSWI/SNF complex VSports手机版. .

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