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. 1999 Mar;44(3):347-52.
doi: 10.1136/gut.44.3.347.

Ciprofloxacin decreases the rate of ethanol elimination in humans

J Tillonen  1 , N Homann, M Rautio, H Jousimies-Somer, M Salaspuro
Affiliations

Ciprofloxacin decreases the rate of ethanol elimination in humans

J Tillonen et al. Gut. 1999 Mar.

Abstract

Background: Extrahepatic ethanol metabolism is postulated to take place via microbial oxidation in the colon, mediated by aerobic and facultative anaerobic bacteria VSports手机版. .

Aims: To evaluate the role of microbial ethanol oxidation in the total elimination rate of ethanol in humans by reducing gut flora with ciprofloxacin. V体育安卓版.

Methods: Ethanol was administered intravenously at the beginning and end of a one week period to eight male volunteers. Between ethanol doses volunteers received 750 mg ciprofloxacin twice daily V体育ios版. .

Results: A highly significant (p=0. 001) reduction in the ethanol elimination rate (EER) was detected after ciprofloxacin medication. Mean (SEM) EER was 107. 0 (5. 3) and 96. 9 (4. 8) mg/kg/h before and after ciprofloxacin, respectively. Faecal Enterobacteriaceae and Enterococcus sp. were totally absent after medication, and faecal acetaldehyde production capacity was significantly (p<0. 05) decreased from 0. 91 (0 VSports最新版本. 15) to 0. 39 (0. 08) nmol/min/mg protein. Mean faecal alcohol dehydrogenase (ADH) activity was significantly (p<0. 05) decreased after medication, but ciprofloxacin did not inhibit human hepatic ADH activity in vitro. .

Conclusions: Ciprofloxacin treatment decreased the ethanol elimination rate by 9 V体育平台登录. 4%, with a concomitant decrease in intestinal aerobic and facultative anaerobic bacteria, faecal ADH activity, and acetaldehyde production. As ciprofloxacin has no effect on liver blood flow, hepatic ADH activity, or cytochrome CYP2E1 activity, these effects are probably caused by the reduction in intestinal flora. .

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Figures (V体育ios版)

Figure 1
Figure 1
Blood ethanol concentrations (mean (SEM)) before and after ciprofloxacin treatment. *p<0.05, **p<0.001, ***p<0.0001.
Figure 2
Figure 2
The effect of ciprofloxacin treatment (750 mg twice a day) for seven days on individual ethanol elimination rates in eight volunteers.
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VSports在线直播 - References

    1. Am J Clin Nutr. 1973 Aug;26(8):831-4 - "V体育官网入口" PubMed
    1. Eur J Biochem. 1986 Jan 2;154(1):119-24 - PubMed
    1. Am J Med. 1987 Feb;82(2):333-8 - PubMed
    1. J Antimicrob Chemother. 1987 Feb;19(2):263-9 - PubMed
    1. Eur J Clin Pharmacol. 1987;32(2):217-8 - PubMed

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