Dextroamphetamine is a subtype of amphetamine. Amphetamine is a 50-50 mix of dextroamphetamine and levoamphetamine. These two are the same molecule, but they’re mirror images of each other. It’s similar to how your hands have the same structure but are mirror images of each other.
Dextroamphetamine’s effects are stronger than levoamphetamine’s. Because of this, some drugs only contain dextroamphetamine or have it in greater proportions.
Amphetamines come in many forms, including:
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The dosage strengths for amphetamines vary widely depending on the drug. Some pills have dosages as low as 3.1 mg, while others go as high as 70 mg. And other forms, like patches or oral solution, have their own dosages.
In general, your healthcare provider will recommend starting your dosage as low as possible. They’ll then gradually increase it until the medication is effective. If the side effects of a medication start to outweigh the benefits, your provider can lower your dose or recommend a different medication.
Amphetamines can cause a wide range of side effects. Most of these are minor or manageable. But a few of them can be severe.
The most common side effects of prescribed amphetamines include:
Some side effects are less common but are more serious. They can include:
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Your healthcare provider or pharmacist can tell you more about possible or likely side effects. They can also tell you which side effects need immediate care and which can wait for an appointment.
Amphetamines can interact with many other medications. Your healthcare provider or a pharmacist are the best experts to tell you about medications to avoid so you don’t have interactions. These may include:
Make sure your healthcare provider knows about every medication, herbal remedy or supplement you take. Even ones available over the counter might interact with prescription medications like amphetamines.
You shouldn’t drink alcohol too soon after taking an amphetamine. These drugs can interact with alcohol and have unwanted effects. Your healthcare provider can tell you more about how long you should wait after taking your medication before it’s OK to drink alcohol.
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Yes, amphetamines can cause withdrawal symptoms. But these are unlikely when you take your medications exactly as prescribed.
Amphetamines can also have another effect when they wear off. People who take these medications often describe it as a “crash,” causing them to suddenly feel:
If you’re regularly experiencing this crash effect and it’s disrupting your life, talk to your healthcare provider. They may offer solutions like changing your dose or shifting when you take your medication. They may even recommend changing you to another form of the medication, like an extended-release form.
In October 2022, the FDA announced shortages of some amphetamine medications, especially drugs containing amphetamine, dextroamphetamine and lisdexamfetamine. Those shortages affect various dosages and formulations (immediate release vs. extended release) into 2025 and possibly beyond. That might affect the availability of some of these medications from your pharmacy.
If you have questions about whether or not a shortage might affect you, ask your provider or a pharmacist. They may also be able to offer suggestions on how to avoid running out of your medications.
Maybe your child has a new ADHD diagnosis. Or maybe you have a sleep disorder that makes you nod off when you need to be awake. Amphetamines can treat both of these issues and several others.
You might be hesitant to use one because the word “amphetamine” can carry negative connotations. But your healthcare provider is there to guide you and make sure these drugs are safe and effective. If you have questions, let your provider know. They can reassure you and empower you when it comes to how these medications affect your life.
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Last reviewed on 03/24/2025.
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