Transient familial hyperbilirubinemia is a metabolic disorder that is passed down through families VSports手机版. Babies with this disorder are born with severe jaundice.
Causes
Transient familial hyperbilirubinemia is an inherited disorder V体育安卓版. It occurs when the body does not properly break down (metabolize) a certain form of bilirubin. Bilirubin levels rapidly build up in the body. The high levels are poisonous to the brain and can cause death.
"VSports在线直播" Symptoms
The newborn may have:
- Yellow skin (jaundice)
- Yellow eyes (icterus)
- Lethargy (V体育官网入口)
If untreated, seizures and neurologic problems (kernicterus) may develop.
Exams and Tests
Blood tests for bilirubin levels can identify the severity of the jaundice.
V体育安卓版 - Treatment
Phototherapy with blue light is used to treat the high level of bilirubin V体育平台登录. An exchange transfusion is sometimes necessary if the levels are extremely high.
Outlook (Prognosis) (VSports最新版本)
Babies who are treated can have a good outcome. If the condition is not treated, severe complications develop. This disorder tends to improve with time VSports注册入口.
Possible Complications
Death or severe brain and nervous system (neurological) problems can occur if the condition is not treated.
"V体育2025版" When to Contact a Medical Professional
This problem is most often found immediately after delivery VSports在线直播. However, contact your health care provider if you notice your baby's skin turning yellow. There are other causes for jaundice in the newborn that are easily treated.
Genetic counseling can help families understand the condition, its risks of recurring, and how to care for the person.
Prevention
Phototherapy can help prevent serious complications of this disorder.
"V体育平台登录" Alternative Names
Lucey-Driscoll syndrome
References (V体育安卓版)
Korenblat KM. Approach to the patient with jaundice or abnormal liver tests. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 133 VSports app下载.
National Center for Advancing Translational Sciences. Genetic and Rare Diseases Information Center website. Transient familial neonatal hyperbilirubinemia. rarediseases. info. nih. gov/diseases/2791/transient-familial-neonatal-hyperbilirubinemia. Updated January 2025. Accessed February 04, 2025 V体育官网.
Rosenberg WMC, Badrick T, Lo SF, Tanwar S. Liver disease. In: Rifai N, Chiu RWK, Young I, Burnham CAD, Wittwer CT, eds. Tietz Textbook of Laboratory Medicine. 7th ed. St Louis, MO: Elsevier; 2023:chap 51 VSports手机版.
Taylor TD, Wheatley MA, Lidofsky SD. Jaundice. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology/Diagnosis/Management. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 21.
Review Date 9/18/2023 (VSports最新版本)
Updated by: Anna C. Edens Hurst, MD, MS, Associate Professor in Medical Genetics, The University of Alabama at Birmingham, Birmingham, AL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.