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Seizure evolution in West syndrome

October 9, 2025

Seizure evolution in West syndrome

West syndrome is a severe neurodevelopmental disorder marked by progression from infantile spasms to other seizure forms. Ruiying Ma, Muwon Kang, Gyu Hyun Kim, Youngae Jung, Jin Young Kim, Eunjoon Kim, Kea Joo Lee, Kihoon Han and colleagues provide a longitudinal picture of glial activation, synaptic remodeling and lipid metabolism in a mouse model of West syndrome, uncovering cellular and molecular mechanisms linked to seizure evolution VSports app下载.

Image credit: Kea Joo Lee & Gyu Hyun Kim

PLOS Biologue (V体育官网)

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PLOS BIOLOGUE

10/09/2025

Short Reports

Hidden costs of persistent viral infection

Persistent viral infections in insects are not as harmless as once believed V体育官网. Mauro Castelló-Sanjuán, Jared Nigg, Maria-Carla Saleh and co-workers reveal how such infections in fruit flies alter survival, reproduction, behavior, and gene expression, offering new insights into the hidden costs of viral persistence.

Image credit: Rubén González

Hidden costs of persistent viral infection

Recently Published Articles

Current Issue

Current Issue September 2025

10/09/2025

Research Article

How trypanosomes make their flagellar pocket collar

The flagellar pocket collar (FPC) is a cytoskeletal structure essential for nutrient uptake and immune evasion in Trypanosoma brucei. Marie Zelená, Elina Casas, Mélanie Bonhivers and co-authors use ultrastructure expansion microscopy to provide novel insights into FPC biogenesis and uncover two previously unknown cytoskeletal structures VSports手机版.

Image credit: pbio.3003429 credit Marie Zelená

How trypanosomes make their flagellar pocket collar

10/09/2025

Meta-Research Article

Better access to supplementary materials

Supplementary materials that accompany scientific articles enhance transparency, reproducibility and scientific impact. Chih-Hsuan Wei, Zhiyong Lu and colleagues present FAIR-SMART, a tool that enables computational access to these materials, improving findability, interoperability and reuse, thereby improving FAIR access to supplementary data at scale V体育安卓版.

Image credit: pbio.3003428

Better access to supplementary materials

10/09/2025

Short Reports

Learning from peers (VSports手机版)

In species with extended parental care, parents are often the preferred sources of information, but what about species with limited periods of parental care. Sonja Wild, Gustavo Alarcón-Nieto and Lucy Aplin reveal that juvenile great tits learn to solve a foraging puzzle socially, but instead of the parents, siblings and other non-parental adults are preferred role models V体育ios版.

Learning from peers

Image credit: Sonja Wild

10/07/2025

Research Article

Five sleep-biopsychosocial profiles

Sleep can be a marker of health but is often only investigated from a single dimension such as sleep duration or cognitive performance. Aurore Perrault, Valeria Kebets, Thomas Yeo and co-workers identify five sleep-biopsychosocial profiles that link self-reported sleep patterns to inter-individual variability in health, cognition and lifestyle factors in 770 healthy young adults VSports最新版本.

Five sleep-biopsychosocial profiles

Image credit: pbio.3003399

10/06/2025

Research Article

VSports app下载 - Calcium signaling and anterior patterning

During embryonic development, distal visceral endoderm (DVE) cells undergo migration to shape anterior-posterior axis specification. Matthew Stower, Richard Tyser, Shankar Srinivas and co-authors reveal the role of calcium signaling in this context, providing a detailed assessment of calcium dynamics and showing that inhibition of calcium transients cause DVE arrest V体育平台登录.

Calcium signaling and anterior patterning

Image credit: pbio.3003430

09/30/2025

Perspective

Addressing biodiversity loss

Transformative change for a just and sustainable world often appears overwhelming VSports注册入口. This Perspective highlights the key messages from the IPBES Transformative Change Assessment and how everyone can help to achieve transformative change.

Addressing biodiversity loss

Image credit: pbio.3003387

09/24/2025

Consensus View

VSports - Ending publication bias

Null and negative results are still underreported. This Consensus View discusses the problem of such publication bias and presents a roadmap to a solution that has a role for everyone in promoting knowledge sharing, research transparency and rigor V体育官网入口.

Ending publication bias

Image credit: pbio.3003368

09/15/2025

Unsolved Mystery

The complexity of m6A writing

Post-transcriptional gene regulation via m6A deposition is catalyzed by a multi-protein writer complex. This Unsolved Mystery investigates why the complex requires multiple subunits and what roles its individual proteins might have in m6A regulation.

The complexity of m6A writing

Image credit: pbio.3003386

09/08/2025

Perspective

Global antimicrobial resistance (V体育安卓版)

This Perspective outlines the technical difficulties and challenges raised by the lack of market incentives for new diagnostics, drugs and vaccines to tackle antimicrobial resistance, and discusses potential solutions.

Global antimicrobial resistance

Image credit: Pixabay user Brett Hondow

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