VSports注册入口 - Van Strijp, Dianne, De Witz, Christiane, Heitkoetter, Birthe (V体育官网), Huss, Sebastian, Boegemann, Martin, Baillie, George S. 
ORCID: https://orcid.org/0000-0003-2469-6316, Houslay, Miles D., Bangma, Chris, Semjonow, Axel and Hoffmann, Ralf
(2019)
The association of the long prostate cancer expressed PDE4D transcripts to poor patient outcome depends on the tumor’s TMPRSS2-ERG fusion status.
Prostate Cancer, 2019,
8107807.
(doi: 10.1155/2019/8107807)
VSports app下载 - Vagena, Eirini, Ryu, Jae Kyu (VSports在线直播), Baeza-Raja, Bernat, Walsh, Nicola M., Syme, Catriona, Day, Jonathan P., Houslay, Miles and Baillie, George ORCID: https://orcid.org/0000-0003-2469-6316
(2019)
A high-fat diet promotes depression-like behavior in mice by suppressing hypothalamic PKA signalling.
Translational Psychiatry, 9(1),
141.
(doi: 10.1038/s41398-019-0470-1)
(PMID:31076569)
(PMCID:PMC6510753)
van Strijp, D. et al V体育官网. (2018) The prognostic PDE4D7 score in a diagnostic biopsy prostate cancer patient cohort with longitudinal biological outcomes. Prostate Cancer, 2018, 5821616. (doi: 10. 1155/2018/5821616) (PMID:30147955) (PMCID:PMC6083737) .
de Inda, M. A. et al. (2018) Validation of cyclic adenosine monophosphate phosphodiesterase-4D7 for its independent contribution to risk stratification in a prostate cancer patient cohort with longitudinal biological outcomes. European Urology Focus, 4(3), pp. 376-384. (doi: 10. 1016/j. euf. 2017. 05 VSports手机版. 010) (PMID:28753810) .
Houslay, Kirsty F. , Christian, Frank ORCID: https://orcid. org/0000-0001-8208-5930, MacLeod, Ruth (VSports最新版本), Adams, David R. , Houslay, Miles D. and Baillie, George S. ORCID: https://orcid. org/0000-0003-2469-6316 (2017) Identification of a multifunctional docking site on the catalytic unit of phosphodiesterase-4 (PDE4) that is utilised by multiple interaction partners. Biochemical Journal, 474(4), pp. 597-609. (doi: 10. 1042/BCJ20160849) (PMID:27993970) (PMCID:PMC5290487) V体育安卓版.
Böttcher, René, Dulla, Kalyan (VSports), van Strijp, Dianne, VSports - Dits, Natasja, Verhoef, Esther I. , Baillie, George S. (VSports) ORCID: https://orcid. org/0000-0003-2469-6316, Van Leenders, Geert J. L. H. , "VSports app下载" Houslay, Miles D. , Jenster, Guido and VSports在线直播 - Hoffmann, Ralf (2016) Human PDE4D isoform composition is deregulated in primary prostate cancer and indicative for disease progression and development of distant metastases. Oncotarget, 7(43), pp. 70669-70684. (doi: 10. 18632/oncotarget V体育ios版. 12204) (PMID:27683107) (PMCID:PMC5342582) .
Havekes, R. et al. (2016) Compartmentalized PDE4A5 signaling impairs hippocampal synaptic plasticity and long-term memory. Journal of Neuroscience, 36(34), pp. 8936-8946. (doi: 10. 1523/JNEUROSCI. 0248-16 VSports最新版本. 2016) (PMID:27559174) (PMCID:PMC4995304) .
Havekes, R. et al. (2016) Sleep deprivation causes memory deficits by negatively impacting neuronal connectivity in hippocampal area CA1. eLife, 5, e13424 V体育平台登录. (doi: 10. 7554/eLife. 13424) (PMID:27549340) (PMCID:PMC4996653) .
Tankou, S. et al. (2016) SUMOylation of DISC1: a potential role in neural progenitor proliferation in the developing cortex VSports注册入口. Molecular Neuropsychiatry, 2(1), pp. 20-27. (doi: 10. 1159/000444257) (PMID:27525255) (PMCID:PMC4979612) .
Bottcher, R. et al. (2015) Human phosphodiesterase 4D7 (PDE4D7) expression is increased in TMPRSS2-ERG positive primary prostate cancer and independently adds to a reduced risk of post-surgical disease progression V体育官网入口. British Journal of Cancer, 113, pp. 1502-1511. (doi: 10. 1038/bjc. 2015. 335) (PMID:26575822) (PMCID:PMC4815894) .
Christian, Frank ORCID: https://orcid. org/0000-0001-8208-5930, "VSports手机版" Krause, Eberhard, Houslay, Miles D. and Baillie, George ORCID: https://orcid. org/0000-0003-2469-6316 (2014) PKA phosphorylation of p62/SQSTM1 regulates PB1 domain interaction partner binding. Biochimica et Biophysica Acta: Molecular Cell Research, 1843(11), pp. 2765-2774. (doi: 10. 1016/j. bbamcr VSports在线直播. 2014. 07. 021) (PMID:25110345) .
Sheppard, C. L. et al. (2014) Mitotic activation of the DISC1-inducible cyclic AMP phosphodiesterase-4D9 (PDE4D9), through multi-site phosphorylation, influences cell cycle progression. Cellular Signalling, 26(9), pp. 1958-1974. (doi: 10. 1016/j. cellsig. 2014. 04. 023) V体育2025版.
V体育ios版 - Boomkamp, S D, McGrath, M A, Houslay, M D and Barnett, S C ORCID: https://orcid.org/0000-0003-1009-0575
(2014)
Epac and the high affinity rolipram binding conformer of PDE4 modulate neurite outgrowth and myelination using an in vitro spinal cord injury model.
British Journal of Pharmacology, 171(9),
pp. 2385-2398.
(doi: 10.1111/bph.12588)
(PMID:24467222)
(PMCID:PMC3997278)
Henderson, D.J.P., Byrne, A., Dulla, K., Jenster, G., Hoffmann, R., Baillie, G.S. ORCID: https://orcid.org/0000-0003-2469-6316 and "VSports app下载" Houslay, M.D.
(2014)
The cAMP phosphodiesterase-4D7 (PDE4D7) is downregulated in androgen-independent prostate cancer cells and mediates proliferation by compartmentalising cAMP at the plasma membrane of VCaP prostate cancer cells.
British Journal of Cancer, 110(5),
pp. 1278-1287.
(doi: 10.1038/bjc.2014.22)
Vandeput, F. et al. (2013) Selective regulation of cyclic nucleotide phosphodiesterase PDE3A isoforms. Proceedings of the National Academy of Sciences of the United States of America, 110(49), pp. 19778-19783. (doi: 10.1073/pnas.1305427110)
"VSports在线直播" Cameron, R.T., Coleman, R.G., V体育安卓版 - Day, J.P., Yalla, K.C., V体育平台登录 - Houslay, M.D., Adams, D.R., VSports在线直播 - Shoichet, B.K. and V体育2025版 - Baillie, G.S. ORCID: https://orcid.org/0000-0003-2469-6316
(2013)
Chemical informatics uncovers a new role for moexipril as a novel inhibitor of cAMP phosphodiesterase-4 (PDE4).
Biochemical Pharmacology, 85(9),
pp. 1297-1305.
(doi: 10.1016/j.bcp.2013.02.026)
(PMID:23473803)
(PMCID:PMC3625111)
Brown, K.M. et al. (2013) Phosphodiesterase-8A binds to and regulates Raf-1 kinase. Proceedings of the National Academy of Sciences of the United States of America, 110(16), E1533-E1542. (doi: 10.1073/pnas.1303004110)
The University Court of The University of Glasgow (2012) Increasing HSP20 Activation in Biological Systems Involves Antagonists Capable of Inhibiting PDE4 Binding. .
Xu, Tian-Rui, "V体育官网" Lu, Rui-Fang, Romano, David, Pitt, Andrew, Houslay, Miles D., V体育平台登录 - Milligan, Graeme ORCID: https://orcid.org/0000-0002-6946-3519 and Kolch, Walter
(2012)
Eukaryotic translation initiation factor 3, subunit a, regulates the extracellular signal-regulated kinase pathway.
Molecular and Cellular Biology, 32(1),
pp. 88-95.
(doi: 10.1128/MCB.05770-11)
Havekes, R., Choi, J.H., Bruinenberg, V., Baillie, G. ORCID: https://orcid.org/0000-0003-2469-6316, Park, A., Day, J., Aton, S., Meerlo, P., Houslay, M. and Abel, T.
(2012)
Blocking the phosphodiesterase isoform PDE4A5 in the hippocampus ameliorates plasticity and memory deficits induced by brief sleep deprivation.
In: Annual Meeting of the Associated-Professional-Sleep-Societies (APSS), Boston, MA, USA, 9-13 June 2012,
A94-A95.
Havekes, R., Choi, J.H., Bruinenberg, V., Baillie, G.S. ORCID: https://orcid.org/0000-0003-2469-6316, Park, A., "VSports" Day, J., Anton, S., Meerlo, P., Houslay, M.D. and Abel, T. (VSports在线直播)
(2012)
Cognitive impairments induced by brief sleep deprivation can be prevented by targeting a single phosphodiesterase isoform selectively in the hippocampus [abstract].
In: 42nd Annual Meeting of the Society-for-Neuroscience, New Orleans, Louisiana, USA, Oct 13 - Oct 17 2012,
Havekes, R., Choi, J.H., VSports在线直播 - Bruinenberg, V., Baillie, G.S. ORCID: https://orcid.org/0000-0003-2469-6316, Park, A., Day, J., Anton, S., Meerlo, P., Houslay, M.D. and Abel, T.
(2012)
Gravin is a key scaffolding protein that orchestrates PKA and beta 2-adrenergic receptor signaling important for long-lasting forms of synaptic plasticity and long-term memory [abstract].
In: 42nd Annual Meeting of the Society for Neuroscience, New Orleans, Louisiana, USA, Oct 13 - Oct 17 2012,
V体育安卓版 - Le Moan, N., "V体育2025版" Houslay, D.M., Christian, F. ORCID: https://orcid.org/0000-0001-8208-5930, Houslay, M.D. (V体育ios版) and V体育官网 - Akassoglou, K.
(2011)
Oxygen-dependent cleavage of the p75 neurotrophin receptor triggers stabilization of HIF-1α.
Molecular Cell, 44(3),
pp. 476-490.
(doi: 10.1016/j.molcel.2011.08.033)
Wang, Q. et al. (2011) The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function. Molecular Psychiatry, 16(10), pp. 1006-1023. (doi: 10.1038/mp.2010.87)
Ishizuka, K. et al. (2011) DISC1-dependent switch from progenitor proliferation to migration in the developing cortex. Nature, 473(7345), pp. 92-96. (doi: 10.1038/nature09859)
MacKenzie, Kirsty F., Wallace, Derek A., Hill, Elaine V., "VSports app下载" Anthony, Diana F., Henderson, David J.P., Houslay, Daniel M., Arthur, J. Simon C., Baillie, George S. ORCID: https://orcid.org/0000-0003-2469-6316 and Houslay, Miles D.
(2011)
Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation.
Biochemical Journal, 435(3),
pp. 755-769.
(doi: 10.1042/BJ20101184)
Sin, Y.Y. ORCID: https://orcid.org/0000-0001-6537-5266, Edwards, H.V., Li, X., Day, J.P. (VSports最新版本), Christian, F. ORCID: https://orcid.org/0000-0001-8208-5930, "VSports最新版本" Dunlop, A.J., Adams, D.R., V体育平台登录 - Zaccolo, M., Houslay, M.D. and Baillie, G.S. ORCID: https://orcid.org/0000-0003-2469-6316
(2011)
Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)–HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes.
Journal of Molecular and Cellular Cardiology, 50(5),
pp. 872-883.
(doi: 10.1016/j.yjmcc.2011.02.006)
(PMID:21334344)
Christian, F. et al. (2011) Small molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes. Journal of Biological Chemistry, 286(11), pp. 9079-9096. (doi: 10.1074/jbc.M110.160614) (PMID:21177871) (PMCID:PMC305896)
Day, J. P. et al. (2011) Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4). Journal of Medicinal Chemistry, 54(9), pp. 3331-3347. (doi: 10.1021/jm200070e)
Anthony, D.F. (V体育安卓版), V体育2025版 - Sin, Y.Y. ORCID: https://orcid.org/0000-0001-6537-5266, "VSports" Vadrevu, S., "V体育官网" Advant, N., Day, J.P., "V体育平台登录" Byrne, A.M., Lynch, M.J., Milligan, G. ORCID: https://orcid.org/0000-0002-6946-3519, VSports app下载 - Houslay, M.D. and Baillie, G.S. ORCID: https://orcid.org/0000-0003-2469-6316
(2011)
β-Arrestin 1 inhibits the GAP function of ARHGAP21 so as to promote the activation of RhoA following angiotensin II type 1A receptor stimulation.
Molecular and Cellular Biology, 31(5),
pp. 1066-1075.
(doi: 10.1128/MCB.00883-10)
(PMID:21173159)
(PMCID:PMC3067824)
Houslay, M.D. (2011) Arresting times for PTEN. EMBO Journal, 30(13), pp. 2513-2515. (doi: 10.1038/emboj.2011.200)
"V体育官网" Houslay, M.D. (2011) Hard times for oncogenic BRAF-expressing melanoma cells. Cancer Cell, 19(1), pp. 3-4. (doi: 10.1016/j.ccr.2011.01.004)
Murdoch, H., Vadrevu, S., Prinz, A., Dunlop, A.J., Klussmann, E., Bolger, G. B., Norman, J. C. and Houslay, M.D. (2011) Interaction between LIS1 and PDE4, and its role in cytoplasmic dynein function. Journal of Cell Science, 124(13), pp. 2253-2266. (doi: 10.1242/jcs.082982)
Perino, A. et al. (2011) Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ. Molecular Cell, 42(1), pp. 84-95.
Burton, P. et al. (2010) Erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) blocks differentiation and maintains the expression of pluripotency markers in human embryonic stem cells. Biochemical Journal, 432(3), pp. 575-584. (doi: 10.1042/BJ20100726)
Kane, N. M. et al. (2010) Lentivirus-mediated reprogramming of somatic cells in the absence of transgenic transcription factors. Molecular Therapy, 18(12), pp. 2139-2145. (doi: 10.1038/mt.2010.231)
Houslay, Miles D. and Christian, Frank ORCID: https://orcid.org/0000-0001-8208-5930
(2010)
p62 (SQSTM1) forms part of a novel, reversible aggregate containing a specific conformer of the cAMP degrading phosphodiesterase, PDE4A4.
Autophagy, 6(8),
pp. 1198-1200.
(doi: 10.4161/auto.6.8.13479)
Kim, Hyun Wook, Ha, Sang Hoon (V体育2025版), Lee, Mi Nam, Huston, Elaine ORCID: https://orcid.org/0009-0001-6978-7134, Kim, Do-Hyung, Jang, Sung Key, Suh, Pann-Ghill (V体育安卓版), Houslay, Miles D. and Ryu, Sung Ho
(2010)
cAMP controls mTOR through regulation of the dynamic interaction between Rheb and Phosphodiesterase 4D.
Molecular and Cellular Biology, 30(22),
pp. 5406-5420.
(doi: 10.1128/MCB.00217-10)
Kim, Hyun Wook, Ha, Sang Hoon, Lee, Mi Nam, Huston, Elaine ORCID: https://orcid.org/0009-0001-6978-7134, Kim, Do-Hyung, Jang, Sung Key, "V体育安卓版" Suh, Pann-Ghill., Houslay, Miles D. and Ryu, Sung H.
(2010)
Cyclic AMP Controls mTOR through Regulation of the Dynamic Interaction between Rheb and Phosphodiesterase 4D.
Molecular and Cellular Biology, 30(22),
pp. 5406-5420.
(doi: 10.1128/MCB.00217-10)
Rampersad, Sarah N., Ovens, Jeffrey D., Huston, Elaine ORCID: https://orcid.org/0009-0001-6978-7134, Umana, M. Bibiana, VSports app下载 - Wilson, Lindsay S., Netherton, Stuart J., Lynch, Martin J. (VSports最新版本), Baillie, George S. ORCID: https://orcid.org/0000-0003-2469-6316, V体育平台登录 - Houslay, Miles D. and Maurice, Donald H.
(2010)
Cyclic AMP Phosphodiesterase 4D (PDE4D) Tethers EPAC1 in a Vascular Endothelial Cadherin (VE-Cad)-based Signaling Complex and Controls cAMP-mediated Vascular Permeability.
Journal of Biological Chemistry, 285(44),
pp. 33614-33622.
(doi: 10.1074/jbc.M110.140004)
Christian, Frank (V体育平台登录) ORCID: https://orcid.org/0000-0001-8208-5930, Anthony, Diana F., "VSports最新版本" Vadrevu, Surakiran, Riddell, Tracy (VSports), Day, Jonathan P., McLeod, Ruth, Adams, David R., Baillie, George S. ORCID: https://orcid.org/0000-0003-2469-6316 and Houslay, Miles D.
(2010)
p62 (SQSTM1) and cyclic AMP phosphodiesterase-4A4 (PDE4A4) locate to a novel, reversible protein aggregate with links to autophagy and proteasome degradation pathways.
Cellular Signalling, 22(10),
pp. 1576-1596.
(doi: 10.1016/j.cellsig.2010.06.003)
Zhu, H. et al. (2010) Evolutionarily Conserved Role of Calcineurin in Phosphodegron-Dependent Degradation of Phosphodiesterase 4D. Molecular and Cellular Biology, 30(18), pp. 4379-4390. (doi: 10.1128/MCB.01193-09)
Burton, P. et al. (2010) Identification and characterization of small-molecule ligands that maintain pluripotency of human embryonic stem cells. Biochemical Society Transactions, 38(4), pp. 1058-1061. (doi: 10.1042/BST0381058)
Kane, Nicole M., "VSports最新版本" Meloni, Marco, Spencer, Helen L., Craig, Margaret A., Strehl, Raimund, Milligan, Graeme, Houslay, Miles D., Mountford, Joanne C., Emanueli, Costanza and Baker, Andrew H. (2010) Derivation of endothelial cells from human embryonic stem cells by directed differentiation: analysis of microRNA and angiogenesis in vitro and in vivo. Arteriosclerosis, Thrombosis, and Vascular Biology, 30(7), pp. 1389-1397. (doi: 10.1161/ATVBAHA.110.204800)
Serrels, Bryan, Sandilands, Emma, Serrels, Alan, Baillie, George ORCID: https://orcid.org/0000-0003-2469-6316, Houslay, Miles D., Brunton, Valerie G., Canel, Marta, Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856, Anderson, Kurt I. and Frame, Margaret C.
(2010)
A complex between FAK, RACK1, and PDE4D5 controls spreading initiation and cancer cell polarity.
Current Biology, 20(12),
pp. 1086-1092.
(doi: 10.1016/j.cub.2010.04.042)
Li, X. et al. (2010) Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK. Biochemical Journal, 428(1), pp. 55-65. (doi: 10.1042/BJ20091672)
Kelly, M. P. et al. (2010) Phosphodiesterase 11A in brain is enriched in ventral hippocampus and deletion causes psychiatric disease-related phenotypes. Proceedings of the National Academy of Sciences of the United States of America, 107(18), pp. 8457-8462. (doi: 10.1073/pnas.1000730107)
V体育ios版 - Bjorgo, Elisa, Solheim, Silje A., "VSports注册入口" Abrahamsen, Hilde, Baillie, George S. ORCID: https://orcid.org/0000-0003-2469-6316, Brown, Kim M., Berge, Torunn, "VSports最新版本" Okkenhaug, Klaus, "V体育平台登录" Houslay, Miles D. and Tasken, Kjetil
(2010)
Cross talk between phosphatidylinositol 3-kinase and cyclic AMP (cAMP)-protein kinase A signaling pathways at the level of a protein kinase B/β-Arrestin/cAMP phosphodiesterase 4 complex.
Molecular and Cellular Biology, 30(7),
pp. 1660-1672.
(doi: 10.1128/MCB.00696-09)
Hayashi-Takagi, A. et al. (2010) Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1. Nature Neuroscience, 13(3), pp. 327-332. (doi: 10.1038/nn.2487)
Houslay, Miles D. (2010) Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown. Trends in Biochemical Sciences, 35(2), pp. 91-100. (doi: 10.1016/j.tibs.2009.09.007)
Schafer, P.H. et al. (2010) Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in vitro and in a model of psoriasis. British Journal of Pharmacology, 159(4), pp. 842-855. (doi: 10.1111/j.1476-5381.2009.00559.x)
Andrews, P. et al. (2010) High content screening of feeder-free human embryonic stem cells to identify pro-survival small molecules. Biochemical Journal, 432(Pt 1), pp. 21-33. (doi: 10.1042/BJ20101022)
Burton, P. et al. (2010) Identification and characterization of small-molecule ligands that maintain pluripotency of human embryonic stem cells. Biochemical Society Transactions, 38(4), pp. 1058-1061. (doi: 10.1042/BST0381058)
VSports注册入口 - Houslay, M.D. and Adams, D.R. (2010) Putting the lid on phosphodiesterase 4. Nature Biotechnology, 28(1), pp. 38-40. (doi: 10.1038/nbt0110-38)
Xu, T. et al. (2010) Inferring signaling pathway topologies from multiple perturbation measurements of specific biochemical species. Science Signaling, 3(113), ra20. (doi: 10.1126/scisignal.2000517)
Vecsey, C. G. et al. (2009) Sleep deprivation impairs cAMP signalling in the hippocampus. Nature, 461(7267), pp. 1122-1125. (doi: 10.1038/nature08488)
Li, X. et al. (2009) A scanning peptide array approach uncovers association sites within the JNK/βarrestin signalling complex. FEBS Letters, 583(20), pp. 3310-3316. (doi: 10.1016/j.febslet.2009.09.035)
"V体育ios版" Houslay, Miles D. (2009) Disrupting specific PDZ domain-mediated interactions for therapeutic benefit. British Journal of Pharmacology, 158(2), pp. 483-485. (doi: 10.1111/j.1476-5381.2009.00359.x)
Kiely, Patrick A., Baillie, George S. ORCID: https://orcid.org/0000-0003-2469-6316, Barrett, Robert, Buckley, Deirdre A., Adams, David R., VSports最新版本 - Houslay, Miles D. and "V体育官网入口" O'Connor, Rosemary
(2009)
Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for IGF-I-mediated regulation of focal adhesion kinase (FAK).
Journal of Biological Chemistry, 284,
pp. 20263-20274.
(doi: 10.1074/jbc.M109.017640)
(PMID:19423701)
(PMCID:PMC2740452)
Li, Xiang, Baillie, George S. ORCID: https://orcid.org/0000-0003-2469-6316 and Houslay, Miles D.
(2009)
Mdm2 directs the ubiquitination of β-arrestin-sequestered cAMP phosphodiesterase-4D5.
Journal of Biological Chemistry, 284(24),
pp. 16170-16182.
(doi: 10.1074/jbc.M109.008078)
"VSports" Ong, W.K., Gribble, F.M. (VSports注册入口), Reimann, F., Lynch, M.J., Houslay, M.D., Baillie, G.S. ORCID: https://orcid.org/0000-0003-2469-6316, Furman, B.L. and "VSports" Pyne, N.J.
(2009)
The role of the PDE4D cAMP phosphodiesterase in the regulation of glucagon-like peptide-1 release.
British Journal of Pharmacology, 157(4),
pp. 633-644.
(doi: 10.1111/j.1476-5381.2009.00194.x)
Meng, Dong, "V体育官网入口" Lynch, Martin J., Huston, Elaine ORCID: https://orcid.org/0009-0001-6978-7134, Beyermann, Michael, Eichhorst, Jenny, Adams, David R., Klusmann, Enno, Houslay, Miles D. and Baillie, George S. (VSports最新版本) ORCID: https://orcid.org/0000-0003-2469-6316
(2009)
MEK1 binds directly to βArrestin1, influencing both its phosphorylation by ERK and the timing of its isoprenaline-stimulated internalization.
Journal of Biological Chemistry, 284(17),
pp. 11425-11435.
(doi: 10.1074/jbc.M806395200)
(PMID:19153083)
(PMCID:PMC2670148)
Houslay, Miles D. (2009) Arrestin times for developing antipsychotics and β-blockers. Science Signaling, 2(66), e22. (doi: 10.1126/scisignal.266pe22)
Terrenoire, Cecile, Houslay, Miles D., Baillie, George S. ORCID: https://orcid.org/0000-0003-2469-6316 and Kass, Robert S. (V体育官网)
(2009)
The Cardiac IKs Potassium Channel Macromolecular Complex Includes the Phosphodiesterase PDE4D3.
Journal of Biological Chemistry, 284(14),
pp. 9140-9146.
(doi: 10.1074/jbc.M805366200)
"V体育安卓版" Collins, Daniel M., Murdoch, Hannah, Dunlop, Allan J., V体育2025版 - Charych, Erik, Baillie, George S. ORCID: https://orcid.org/0000-0003-2469-6316, Wang, Qi, "V体育2025版" Herberg, Friedrich W., Brandon, Nicholas, Prinz, Anke and Houslay, Miles D. (VSports app下载)
(2008)
Ndel1 alters its conformation by sequestering cAMP-specific phosphodiesterase-4D3 (PDE4D3) in a manner that is dynamically regulated through Protein Kinase A (PKA).
Cellular Signalling, 20(12),
pp. 2356-2369.
(doi: 10.1016/j.cellsig.2008.09.017)
McCahill, Angela, Campbell, Lachlan, McSorley, Theresa (VSports注册入口), Lynch, Martin J., Li, Xiang, V体育安卓版 - Yang, Cheng, Baillie, George S. ORCID: https://orcid.org/0000-0003-2469-6316, "V体育2025版" Houslay, Miles D. and Sood, Arvind
(2008)
In cardiac myocytes, cAMP elevation triggers the down-regulation of transcripts and promoter activity for cyclic AMP phosphodiesterase-4A10 (PDE4A10).
Cellular Signalling, 20(11),
pp. 2071-2083.
(doi: 10.1016/j.cellsig.2008.07.017)
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Proceedings of the National Academy of Sciences of the United States of America, 105(35),
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"VSports最新版本" Kiely, Patrick A., Baillie, George S. ORCID: https://orcid.org/0000-0003-2469-6316, Lynch, Martin J., VSports - Houslay, Miles D. and O'Connor, Rosemary
(2008)
Tyrosine 302 in RACK1 is essential for insulin-like growth factor-I-mediated competitive binding of PP2A and {beta}1 integrin and for tumor cell proliferation and migration.
Journal of Biological Chemistry, 283(34),
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(2008)
Mutations of β-arrestin 2 that limit self-association also interfere with interactions with the β2-adrenoceptor and the ERK1/2 MAPKs: implications for β2-adrenoceptor signalling via the ERK1/2 MAPKs.
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V体育2025版 - Shepherd, MC, Baillie, GS (VSports在线直播) ORCID: https://orcid.org/0000-0003-2469-6316, Stirling, DI and Houslay, MD
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Baillie, G. et al. (2002) TAPAS-1, a novel microdomaln within the unique N-terminal region of the PDE4A1 cAMP-specific phosphodiesterase that allows rapid, Ca2+-triggered membrane association with selectivity for interaction with phosphatidic acid. Journal of Biological Chemistry, 277, pp. 28298-28309. (doi: 10.1074/jbc.M108353200)
Beard, MB, VSports手机版 - Huston, E, Campbell, L, "VSports最新版本" Gall, I, VSports手机版 - McPhee, I, Yarwood, S (VSports在线直播), Scotland, G (V体育安卓版) and Houslay, MD (2002) In addition to the SH3 binding region, multiple regions within the N-terminal noncatalytic portion of the cAMP-specific phosphodiesterase, PDE4A5, contribute to its intracellular targeting. Cellular Signalling, 14, pp. 453-465.
"VSports最新版本" Le Jeune, IR, Shepherd, M, Van Heeke, G, Houslay, MD (V体育安卓版) and Hall, IP (2002) Cyclic AMP-dependent transcriptional up-regulation of phosphodiesterase 4D5 in human airway smooth muscle cells - Identification and characterization of a novel PDE4D5 promoter. Journal of Biological Chemistry, 277, pp. 35980-35989. (doi: 10.1074/jbc.M204832200)
MacKenzie, SJ, Baillie, GS ORCID: https://orcid.org/0000-0003-2469-6316, "VSports手机版" McPhee, I, MacKenzie, C, Seamons, R, McSorley, T, Millen, J, Beard, MB, van Heeke, G (VSports) and VSports - Houslay, MD
(2002)
Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1).
British Journal of Pharmacology, 136,
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McCahill, A, Warwicker, J, "VSports最新版本" Bolger, GB, "V体育ios版" Houslay, MD and Yarwood, SJ (2002) The RACK1 scaffold protein: A dynamic cog in cell response mechanisms. Molecular Pharmacology, 62, pp. 1261-1273.
Perry, S. et al. (2002) Targeting of cyclic AMP degradation to beta(2)-adrenergic receptors by beta-arrestins. Science, 298, pp. 834-836.
Poghosyan, Z, Robbins, SM, Houslay, MD, Webster, A (VSports在线直播), Murphy, G and Edwards, DR (2002) Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases. Journal of Biological Chemistry, 277, pp. 4999-5007. (doi: 10.1074/jbc.M107430200)
Baillie, G ORCID: https://orcid.org/0000-0003-2469-6316, MacKenzie, SJ and Houslay, MD
(2001)
Phorbol 12-myristate 13-acetate triggers the protein kinase A-mediated phosphorylation and activation of the PDE4D5 cAMP phosphodiesterase in human aortic smooth muscle cells through a route involving extracellular signal regulated kinase (ERK).
Molecular Pharmacology, 60,
pp. 1100-1111.
Dodge, K.L., Khouangsathiene, S., Kapiloff, M.S., Mouton, R., Hill, E.V., "VSports手机版" Houslay, M.D., VSports - Langeberg, L.K. and "VSports app下载" Scott, J.D. (2001) mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module. EMBO Journal, 20, pp. 1921-1930.
Faroqui, SM, Al-Bagdadi, F, V体育ios版 - Houslay, MD, Bolger, GB, Stout, R, Specian, RD, Cherry, JA, Conti, M and ODonnell, JM (VSports app下载) (2001) Surgically induced cryptorchidism-related degenerative changes in spermatogonia are associated with loss of cyclic adenosine monophosphate-dependent phosphodiesterases type 4 in abdominal testes of rats. Biology of Reproduction, 64, pp. 1583-1589.
V体育官网入口 - Houslay, M (2001) Development of rolipram-sensitive, cyclic AMP phosphodiesterase (PDE4) in rat primary neuronal cultures. Developmental Brain Research, 130(1), pp. 115-121. (doi: 10.1016/S0165-3806(01)00219-X)
"VSports在线直播" Houslay, M (2001) Intracellular targeting and regulation of PDE4 cAMP specific Phosphodiesterases. Progress in Nucleic Acid Research and Molecular Biology, 69, pp. 249-315. (doi: 10.1016/S0079-6603(01)69049-4)
Houslay, MD (2001) PDE4 cAMP-specific phosphodiesterases. Progress in Nucleic Acid Research and Molecular Biology, 69, pp. 249-315.
Makhay, MM, "VSports最新版本" Houslay, MD and ODonnell, JM (2001) Discriminative stimulus effects of the type-4 phosphodiesterase inhibitor rolipram in rats. Psychopharmacology, 158, pp. 297-304.
McPhee, I, Cochran, S and Houslay, MD (2001) The novel long PDE4A10 cyclic AMP phosphodiesterase shows a pattern of expression within brain that is distinct from the long PDE4A5 and short PDE4A1 isoforms. Cellular Signalling, 13, pp. 911-918.
Rena, G, Begg, F, VSports手机版 - Ross, A, Mackenzie, C, Mcphee, I, Campbell, L, Huston, E, Sullivan, M (VSports) and V体育平台登录 - Houslay, MD (2001) Molecular cloning, genomic positioning, promoter identification, and characterization of the novel cyclic AMP-specific phosphodiesterase PDE4A10. Molecular Pharmacology, 59, pp. 996-1011.
Staples, KJ, Bergmann, M, Tomita, K, Houslay, MD (VSports在线直播), McPhee, I, Barnes, PJ, Giembycz, MA and Newton, R (2001) Adenosine 3 ',5 '-cyclic monophosphate (cAMP)-dependent inhibition of IL-5 from human T lymphocytes is not mediated by the cAMP-dependent protein kinase A(1). Journal of Immunology, 167, pp. 2074-2080.
Steele, MR, McCahill, A, Thompson, DS, MacKenzie, C (VSports注册入口), "VSports最新版本" Isaacs, NW, Houslay, MD and Bolger, GB (2001) Identification of a surface on the beta-propeller protein RACK1 that interacts with the cAMP-specific phosphodiesterase PDE4D5. Cellular Signalling, 13, pp. 507-513.
"VSports" Michie, Alison M. ORCID: https://orcid.org/0000-0002-5404-475X, Rena, Graham, Harnett, Margaret M. ORCID: https://orcid.org/0000-0001-5740-3028 and Houslay, Miles D.
(1998)
Upregulation of cAMP-specific PDE-4 activity following ligation of the TCR complex on thymocytes is blocked by selective inhibitors of protein kinase C and tyrosyl kinases.
Cell Biochemistry and Biophysics, 28(2-3),
pp. 161-185.
(doi: 10.1007/BF02737810)
Tobias, E.S. ORCID: https://orcid.org/0000-0003-2649-7695, "VSports在线直播" Rozengurt, E., Connell, J. and Houslay, M.D.
(1997)
Co-transfection with protein kinase D confers phorbol-ester-mediated inhibition on glucagon-stimulated cAMP accumulation in COS cells transfected to overexpress glucagon receptors.
Biochemical Journal, 326(2),
pp. 545-551.
Michie, A.M. ORCID: https://orcid.org/0000-0002-5404-475X, Harnett, M.M. ORCID: https://orcid.org/0000-0001-5740-3028 and "VSports最新版本" Houslay, M.D.
(1997)
Cyclic nucleotide signalling throughout T cell maturation.
In: VSports app下载 - Harnett, M.M. and Rigley, K.P. (eds.)
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John Wiley & Sons Ltd.: Chichester, p. 247.
ISBN 9780471959038
Michie, Alison M. ORCID: https://orcid.org/0000-0002-5404-475X, Lobban, Margaret (VSports手机版), Müller, Thomas, Harnett, Margaret M. ORCID: https://orcid.org/0000-0001-5740-3028 and Houslay, Miles D.
(1996)
Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity following ligation of the T cell antigen receptor on thymocytes: analysis using the selective inhibitors erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) and rolipram.
Cellular Signalling, 8(2),
pp. 97-110.
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Shakur, Y., Wilson, M. (VSports注册入口), VSports最新版本 - Pooley, L., Lobban, M., Griffiths, S.L., Campbell, A.M., Beattie, J., Daly, C. ORCID: https://orcid.org/0000-0002-0410-7548 and Houslay, M.D.
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Identification and characterization of the type-IVA cyclic AMP-specific phosphodiesterase RD1 as a membrane-bound protein expressed in cerebellum.
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Houslay, M.D. et al. (1995) Alternative splicing of the type-IVA cyclic AMP phosphodiesterase gene provides isoform variants with distinct N-terminal domains fused to a common, soluble catalytic unit: ‘designer’ changes in Vmax, stability and membrane association. Biochemical Society Transactions, 23, pp. 393-398.
Pyne, N.J., "VSports手机版" Cushley, W., Nimmo, H.G. ORCID: https://orcid.org/0000-0003-1389-7147 and Houslay, M.D.
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Insulin stimulates the tyrosyl phosphorylation and activation of the 52 kDa peripheral plasma-membrane cyclic AMP phosphodiesterase in intact hepatocytes.
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(doi: 10.1042/bj2610897)
(PMID:2478121)
(PMCID:PMC1138914)
Pyne, N.J., Anderson, N., VSports在线直播 - Lavan, B.E., Milligan, G. ORCID: https://orcid.org/0000-0002-6946-3519, "V体育ios版" Nimmo, H.G. ORCID: https://orcid.org/0000-0003-1389-7147 and Houslay, M.D.
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Specific antibodies and the selective inhibitor ICI 118233 demonstrate that the hormonally stimulated 'dense-vesicle' and peripheral-plasma-membrane cyclic AMP phosphodiesterases display distinct tissue distributions in the rat.
Biochemical Journal, 248(3),
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(doi: 10.1042/bj2480897)
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(PMCID:PMC1148634)
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A novel method for the purification of the insulin-activated peripheral plasma membrane, high-affinity cyclic AMP phosphodiesterase.
Biochemical Society Transactions, 14(6),
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(doi: 10.1042/bst0141016)
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