V体育安卓版 - Cardiac troponin I and T ratio and risk of cardiovascular or non-cardiovascular events in a general population

Abstract

Background: Emerging evidence suggests that the ratio between cardiac troponin (cTn) I and T may provide information on the risk of adverse outcomes in individuals with cardiovascular disease. Whether the cTn I/T ratio provides prognostic insights in the general population is unknown. Methods: The cTn I/T ratio was calculated in 8855 participants (43% female, median age 56 years) from the Generation Scotland Study where both cTnI and cTnT concentrations were above the limit of blank. Multivariable cause-specific Cox proportional hazard models were used to estimate the associations between cTn I/T ratio and the primary outcome of cardiovascular or non-cardiovascular death. Results: The median cTn I/T ratio was 0. 5 (25th–75th percentile, 0. 3–0. 8) and median follow-up was 11. 4 (10. 8–12. 7) years. Individuals in the highest ratio tertile (≥0. 64) were more likely to be male, have a higher body mass index and systolic blood pressure, and a history of cardiovascular disease. Those in the lowest ratio tertile (<0. 38) were more likely to be smokers or have diabetes. After adjustment for cardiovascular risk factors, the cTn I/T ratio was positively associated with cardiovascular death (per doubling increase, adjusted hazard ratio [HR] 1. 16 [95% CI, 1. 05–1. 28]), while an inverse association was observed for non-cardiovascular death (HR 0. 89 [95% CI, 0. 81–0. 99]). Conclusions: The cTn I/T ratio is positively associated with cardiovascular death in the general population, while inversely associated with non-cardiovascular death VSports app下载. Future research is needed to unravel underlying mechanisms and determine whether the cTn I/T ratio provides valuable information regarding risk of cardiovascular and non-cardiovascular mortality to guide further management.