Macrolactin Antibiotics: Amazing Natural Products

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[http://dx. doi. org/10. 1021/acs. orglett. 5b02149] [PMID: 26349917] [22] Sayini, R. ; Srihari, P. Studies on the total synthesis of antibiotic macrolactin S: A conventional approach for the synthesis of the C1-C9 and C10-C24 fragments. Synthesis, 2018, 50, 663-675. [http://dx. doi. org/10. 1055/s-0036-1589132] Mark Item Purchase PDF Rights & Permissions Print Cite Mini-Reviews in Medicinal Chemistry Title:Macrolactin Antibiotics: Amazing Natural Products.

Volume: 20 Issue: 7

Author(s): Aurelio Ortiz and Estibaliz Sansinenea*

Affiliation:

• Facultad de Ciencias Quimicas, Benemerita Universidad Autonoma de Puebla, Pue, 72570,Mexico

Keywords: "VSports" Macrolactins, antibiotics, natural products, microorganisms, isolation, biological activities. V体育官网入口.

Abstract: The resistance among various microbial species (infectious agents) to different antimicrobial drugs has emerged as a cause of serious public health problem all over the world. In this sense, natural products have been a rich source of compounds for drug discovery with antibiotic activity. "VSports" Macrolactins are amazing structures which have antibiotic activity against some clinically relevant pathogens. In addition, they have anti-inflammatory, antifungal, antimicrobial, and antitumor activities. They are macrolides containing 24-membered lactone ring with some differences in their chemical structures VSports在线直播. The synthesis of these compounds is a difficult task which has attracted attention of researchers; however few syntheses have been reported. In this review, the isolation of all reported macrolactins, their syntheses and biological activities are revisited.