Development of epigallocatechin gallate-eluting polymeric stent and its physicochemical, biomechanical and biological evaluations

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Published 8 July 2009 • 2009 IOP Publishing Ltd Biomedical Materials (VSports注册入口), Volume 4, Number 4Citation Dong-Wook Han et al 2009 Biomed V体育安卓版. Mater. 4 044104DOI 10. 1088/1748-6041/4/4/044104.

Dong-Wook Han

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Department of Nanomedical Engineering, College of Nanoscience & Nanotechnology, Pusan National University, Busan 609-735, Korea

Department of Medical Simulation Engineering, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan

Jun Jae Lee

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Division of Advanced Fibro-Science, Kyoto Institute of Technology, Kyoto 606-8585, Japan

Duk-Young Jung

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Senior Products Industrial Center, Busan Techno-Park, Busan-617-030, Korea

Jong-Chul Park

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Cellbiocontrol Laboratory, Department of Medical Engineering, Yonsei University College of Medicine, Seoul 120-752, Korea

Suong-Hyu Hyon

AFFILIATIONS

Department of Medical Simulation Engineering, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan

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Dates

  1. Received 9 December 2008
  2. Accepted 16 April 2009
  3. Published

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Abstract

Localized drug delivery from drug-eluting stents has been accepted as one of the most promising treatment methods for preventing restenosis after stenting. However, hypersensitivity reactions caused by their nonresorbable polymer coatings and bare-metal stents may result in serious clinical sequelae. Epigallocatechin-3-O-gallate (EGCG), the predominant catechin from tea, has been shown to exert anti-thrombotic, anti-inflammatory and anti-proliferative activities V体育官网入口. In this study, it was hypothesized that sustainedly released EGCG from biodegradable poly(lactide-co-蔚-caprolactone, PLCL) would suppress the proliferation of vascular smooth muscle cells (VSMCs). EGCG-releasing PLCL (E-PLCL) was prepared by blending PLCL with EGCG. The surface morphology, roughness and melting temperature of PLCL were not changed despite EGCG addition. EGCG was uniformly dispersed into E-PLCL and sustainedly released for periods up to 7 days by controlled diffusion rather than PLCL degradation. Moreover, EGCG did not affect tensile strength at break, but significantly increased the elastic modulus of PLCL. The proliferation of VSMCs onto E-PLCL was significantly suppressed although the cell attachment onto E-PLCL had been higher than that onto PLCL. On the other hand, EGCG-eluting polymeric stents were prepared with neither cracks nor webbings between struts, and their structural integrity was maintained without delamination or destruction. These results suggest that E-PLCL can be potentially applied for fabricating an EGCG-eluting vascular stent, namely an EGCG-eluting polymeric stent, or even an EGCG-releasing polymer-coated metal stent, to prevent thrombosis, inflammation and in-stent restenosis.

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10.1088/1748-6041/4/4/044104

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