JFIF,,Photoshop 3.08BIM8BIM%F &Vڰw8BIM,,8BIM&?8BIM 8BIM8BIM 8BIM 8BIM' 8BIMH/fflff/ff2Z5-8BIMp8BIM@@8BIM8BIMW pone.0064138.g002 nullboundsObjcRct1Top longLeftlongBtomlongRghtlong slicesVlLsObjcslicesliceIDlonggroupIDlongoriginenum ESliceOrigin autoGeneratedTypeenum ESliceTypeImg boundsObjcRct1Top longLeftlongBtomlongRghtlong urlTEXTnullTEXTMsgeTEXTaltTagTEXTcellTextIsHTMLboolcellTextTEXT horzAlignenumESliceHorzAligndefault vertAlignenumESliceVertAligndefault bgColorTypeenumESliceBGColorTypeNone topOutsetlong leftOutsetlong bottomOutsetlong rightOutsetlong8BIM( ?8BIM8BIM 7g JFIFHH Adobe_CMAdobed            7" ?   3!1AQa"q2B#$Rb34rC%Scs5&DTdE£t6UeuF'Vfv7GWgw5!1AQaq"2B#R3$brCScs4%&5DTdEU6teuFVfv'7GWgw ?TI%4YzFL} `@w{~+u+m^4 b xn( :PF{}/˃e!w /Mt :N ~]-v,z{$ǩ1[&fENUc.ڲ!t9mDֻSiĪSfV62Yiw8ZI<#3x~_Wjֆ 'rz6}ߥ0ZwKtEIՐ?G|.e{,w9V]sgI;u3vl7b$uh${J[?ܪTzLDWD{y]E'Qޞmjs繾^Em%khq:^ls+^{D7E5LZ}syץMA'IJI$RI$I%?TLHIRR& RI$CTǺt4Y])"JJ{z6w¶\&( 0}c,mbhgbUcbA*ti/smߠgU:am{Gk8ZdžKe$.Wrk%ݥ6nۻ2sINj&BF8_!I$$A#I$I%?j)eRc1mmաu|l7f[9/K6kLV;)2^6FY1;;CK#H~1⏤ qNM>[<ἵ35vpDħ] 'So)kO +X2հt55; %g>Iol~^,KwL۾6z6߳ٽ6\__U ~}-Xx'߬<@9"kuMunŀ\KYn年km17C2=?ϴc64eu_a&?[1++yB4H#wZf %wHZs63 k)o^'?*:ۺ?K/q[kƗo!68`Z^j5&5el{knΟՃK%ٯ{?n243vV_C[H(;x߽O+77Mx,Ujڲ5NSEns厂G{?,l[rx8?i%Ж|ΒJ~2rdsN-",x 9`{=8 I)EuPI|̰>=s˷k9)$41d&?yW%b ]I)}+(n'浵]!>kfZ$5땯IOu78m6u 1Obk2.c[mpۖI)Dz<+,r2U$8BIM!UAdobe PhotoshopAdobe Photoshop CS28BIM maniIRFR8BIMAnDsnullAFStlongFrInVlLsObjcnullFrIDlongreFrGAdoub@>FStsVlLsObjcnullFsIDlongAFrmlongFsFrVlLslongreLCntlong8BIMRoll8BIMmfrihttp://ns.adobe.com/xap/1.0/ 2013-05-31 Schematic of the process of generating clinical grade CD19-specific T cells.A MCB (PACT) and WCB (MDACC) were generated for K562-derived aAPC (clone #4). For the generation of CAR+ T cells, aAPC were numerically expanded in bags, harvested using the Sepax II system, irradiated (100 Gy), and cryopreserved for later use. CD19-specific T cells were manufactured as follows; PBMC were isolated from normal donor apheresis products using the Sepax II system and cryopreserved. The PBMC were later thawed, electroporated with the SB DNA plasmids (CD19RCD28 CAR transposon, SB11 transposase) using the Nucleofector System, co-cultured with thawed irradiated aAPC along with cytokines (IL-2 and IL-21) for a culture period of 28 days and cryopreserved. info:doi/info:doi/10.1371/journal.pone.0064138.g002 Public Library of Science Figure 2 Creative Commons Attribution License info:doi/10.1371/journal.pone.0064138 C       C " X !"1A #2QBWaq$3UuRV478Sbr6CDcdt&f;!1AQaq"23BR#Cbr ?N)@)JP R)@)JP RVMZq+Q]euqlQH̕vDDUvDU@2LHf׫[F}.4;<oڀRRן˶bx!+{c1Zu8qOt!2vPf4 ktѹSq䈪$$E"v%T]R()JJRR()JJRR()JZRujf:[nd9HIWIYi҉nbnx[o:ġ!Mw)A 8"sq9&b.| o 24V mlG v1V{~IWbUMU͹Gx`di~$xq N*ʷ*`/d}y׈ɉAMhkWr-8E:s*\6j'4UO~~[Lkb+heñ(jT&dNrR} 4lLԕ%"%UQw_5ͣYWN[_].\ieeK%/ z ۣυ[4ˈ:O>j +Fk*P;6a1nePѩ8K ,xe) mǸnlD2쪵:S -UXM3,L:RoLbBv\V ((!U]ԁPEp3mqUDR]"*juO .\{E.2 Knt r}Л"!yYRqx>kISSHQ_Ltfio t׷bH:@iZ$@MP%RuUķLJR-h $;n趪ڢs|(ng+fB5`,_9ۿ ogt_R[R.W`tǝ//u o`bDM-j}͵:.zpl S5^MdQE"nUWlWrSO-酏C{J+e^W.R[uPpX4x̒!"ODU~īBWJY_#SZ-^OBR?VjmVlGW%Ԩ =峨y <2pn8D&F!)"6UE3PCuwNQ1wqƥMAEU%'PQUXDDvΟkZ-lԆ1V5diM+c3u+$[@XIq?ٽw/wNfF@9"DSwUQ¸_,SuV[س 5$-3_;"'p֡iCiϴڧGdD JȱϧDis$P#}XE&8eƔeZ58( IуtF'Q(J.[*ʽu-7*?rWnrNg_:T>F)\|R()JJRR()JJRR()JJRR()JJRR()JJRR()JJRR(Ar䷿S܊*x!MmZ}%D0_tE**UcQ4 j;WsD1~b^HSK\!UѶ5ijey WiM5J=iqѷT|8^xe E쿓 Uw?EFY&wu j|"&hlmFO/_ys:It{E+Щ)SM6polɧLF%0ln#@H6[]ѦUAE%U7eӏ_a[i\b^KmFI_ Q8|Dٯ,&B)R(2u#dYa43Ŕ LMUI]^vSmL:+n6{.}(*5VbWV/v{]bݺHx ADWrNcBGۙq0@vqW~+{Ϸٟ>vi[B-w+ඃ~d;{N"ovgsmLb\ҟ;x:Q@PIB!DU$zw҆cѮkIv~ ^ :?DymdiA )zYl[8qr[}#d;(擭02 |eEؼnIx!TTTT5+gZ TK}{!",#<&bIQQwEJP R2x3wʮ,J~- Ei]xe2> vJzЈ3.v;*L˂g1ԁ(w}[y~C3rbvOml22F).ܛ/A]Ar(Hvڸxm俯ڮ멾߇WrN[Fro2N"S޾>4Éd9L%&/6%ժK.̉2+Bf "2$[`YҮnis;lIm;ۀVTN{n)W}Z@/&/gy$9[nKhJ2! "H9 "BS;ej] fdIr8h$;$"J RI[#is6u+PY:SX0 cGXMM컿U[sdTZXQf(6)xtBV%F>@|I@ "BEDTTI2()JJRR()JJRR()JJRR()JJRR()JJRR()JU%sIqDzga7A4oҊYi'_ #L :Wޛt_"S .YO† uץerKE=\aDޔ@pT%*&n8=ND2XE"EOÈk(V{x T}Tڹ۴+ݧnm 0Dq Del9J]D <}o3gmM`\2R]~Cv1"В#-*,%8ٟy-O5$\ oWa8,W+emQqSuR"#5S3"R"2U""UUUUZeJPAXY#&9x.eCg-Q%Rq<"n_X'f\dn^4!+rg)$qDvh6퓊Ӊyډon"p`JIޅpLgfқOpVt& P[OI}<خ.v6(7bHiqk6#"!A2] |(Mf28xwr$z+_V?slX>$_Fh"udh&Y)20n"ObL.)$N:G?|F+tŤ۔GN GyeGm#>NED(%ܷÏG9Ų3vhH{h 6 dsIPBUN[ t.kܱ뫘;') t$9oexm$bJrMz}[VwOT*'nh$" Q[4H@*5-ӢVWO0anb'Pvؑ(c"#-OD;v\~tfd]#(4DMjikjG3^m;"l3ʎaiÂtie̵8"l4h1 iM5RB憈(+kVh& [KO,1!G6q_UqtRt^18Zs'&EuT(A$4E؆6{gj<ۓS" EqF 豥9 |w0pAEFL4>䗙4c ؉[C|E tlPQ 5O!ՐɼD)i-0e1riTyn "l6m)@)JP ]Ȋ֭n;m*TnM#6#"n/{l Ǩfh0lg d *#rVl;j@JBV!vKqc>][irFi5n;l2Az[yӻ"b|f}cmm[~7u 9E5md]GM@vp+SJH"|0{MsxW['; ")@ (X<\7/tՖdk$9ޓiόo۲!4SȫBMK`/uso*ľYHoIGH`ۊmeo hd`3|)B8 gQI✚yEivy QvKFrve)P-6Ȗf`XzUR̆EnPJ5U$TUUO\)L+Va ^32"C)!V\-Xm ݮHDnWDNgXEؓ6܀ovv8wιj&JvS*ɾɲ"%D@GIi'<%%}E>˂ۙh@)@)JP R)@)JP R)@)JP R)@)JP R)@)JP R)@)JP R)@)JP R)@)JP R)@)JP R)@)JP R^EXH#qvtXhEuם/m)kDUvE]-֦W;Pћq\e!hHD)( vAqQUDUI7TD_:"L F&-0C슩.웭ǫOQ7VL}C6$*|PS l[2eb47ow)Mu?lyoP **avln^5T<{9ĐPQI6Yd1: ̆  =*~ %EE+]RZ?".Y+Kf$BK3y7\|W$6h6%Luj:cD F##a&gqtJ2[I\w$)/FF mmiY!1WFqH@V"U m`i'g %c0%bl3Li^ +RR()JJRR()JJRR()JJRR()JJRR()JJRR()JJRR()JJRR()JJRR()JJRR(tYrar%!}x%T2O"H -$T]Q`!f]R^MHke֡]T0R-Jryk5TܷZJ7cSz-oT+ΦY6v7e%F6([쪞QܹdZ6V)“~d6m8/-7T*eze56mmF/2`%Dr59sp oE rTelN¸'ALGtEDUvJס<)@)JP R)@)JP R)@)JP R)@)JP R)@)JP R)@)JP R)@)JP R)@)JP R)@)JP Trͩ:ud 3ϱ˞AiG}ՇD@4!䉲"Z_r<{W\nBФϔMIw3TO$^«Z#JH޵J͏6=\[ P؎@:"EEDTЭ Ѻo8*-d")HRu7+u+Т2!mE]'D%e D(#`2]vA%E;ԥ()JZf;wynm[n7m-˘:/qcwd6*+k|Ҁ>~.1`duyd6Vdqe&ĔvK:M1Օ%lUEU{Ӿ 2vʔUv iy tXc3!Dc"2ThЈ*V;);QѠkɶ꿍rRR()JJ]2f5m$Fw:!]樛%CgnC? o}[Uʬ#mаR-߲lV: -Dl:^DIBC;QU"Ke%D]uwrǦ!wو񳿶ܐw~;~wvxѻkZop"%jRKXBA")@)JP R)@)JP Rr}]Pv>Y&#+QeCEs~ꛂvBMMt;^fF#ʆ83 < e, +m.U6/Re5U`ZK4^Q6A]M!X?/v?p]w|L@Ң/ήzW_8ωWSUzX< -3YQD[VIpݑE4xEWHlg579G!8vj/ّDݬGfTED_.1-AV׊A7K,nW)vQwWֵ: U2|#wQ6EpUQ7OΫ%?D[]ͽ땮 ҌԘfAG)x6g==QLu[J<)즱HnuENHk`#u73l2HYD96D&GqQQQe_~5kt7>RƚUox"~TOYe-F.#ͣ-ѼȮӥqc,I[r'P`:,\BQ/Jjad#<衃HBBʊ+3()JQLw-ER6E7M2XM[0`)# Io 슩n \~{e$[qni[tS~}7};֪ݾh9 .;;UK1iTi"&]tW"'O(K8ZjI6*m89IwTQU>I\3n7ik+~3ܝ ,)6+O~VN()JJR/;SAEQ7D}]U|~žYduO˄ Doo^?tfu Ge0QEH* }Q}>j[?W/TէoxǔI֚kGd4* DQWٛ. B+庚~M ]^M-9aЪ:H."#mVTCN"ޱϼEQz%),Tqt*YN6Q'ѹ:N:jj苅zVЬ0m/Dx۠BD.V]}8~FXKbXj dgţdI(@EW$ /ImɨeYY[ieC75YGۉ@Gn*|ʛ6{)qPt[mt3@v5&=8Nj0^{xDzƍ>i~TT_֕ߪu>*H`PJn AQ*j(&֧3hLc%|sn NW~-'ur*$ؔ* ()JJRR()JJVcb!r$+\[# 1Wnr \9|#DbyWJj]ҔeB - [.-*:֌\v$h ',zkn)d4x}! 6KdC\*JY\`$$ هd7UD| n/M|%DMT{/J Ƭ"m+/{j*=IeasM=¶]/nÎą<"'Гm~gDm@MQN;J{* 1!]SqVf~ߢqHO@pǾò.>D((oK()J%mnDVW-kgM}`8U)-:FLsQj[NlEWmoƦE6?^gm~iR789-x'Յ3 epTp\lQ:/TRS{&^U6XQ\Y5ž,-I_J *HOV:s{ֹQ!J8|vm?Kl7EUD$EE|*oxTZʽ)Tt5kbkW/+ɯ9oܟ ?;m'fU-.KmYRK͗CJT&mX8sayS!M"(D'̉*73P Rg92oy0Sf}GOsI[8S~8 J&ŵDjp \MK0̖uE !~[G5fڧl4HdDm]gҤ_8(#įP#-6#;[ n#jH)@*s]y1EP>"vapB2l9̔Ka"g3}bMzKB6*$:cyMl٦EnrJ0  ˷ {"%9+xYp*mQQ7쿱hJUaXOeze2 eX.MrO7H"#Č DD D֚ 0{6MT+r;ee\or s@ɸ” LJdFZ#el쪞Q}5,/"Ww*4M(d޲E幖+L'J] p$^%7 6ʴЪ7z\!V?omKli$[@:V@LwP\^m✰\|~kv8mp8: )pBTO'μB5$!g&2=5zkp"/<{'>ξe oŕm+3##8|ȉ1 w\#MܒH:Yň$jWl҈9ø%6Gv)8t=Ft(-<.,lOͻ#:16C|aOonL.1ձ]QurVP tJ\zEhעNoRQUx"&&w8G,ڙ.:͜cG$WmUֈ@&R.鿊A K[+Zd%Cq\O *wc )6nNYL.$f4x- V8LՇ%rxғCm WT8\H|/l_lq٨*tT/VȋejQI,3ɼKmwlݷLmptQv6m "/c.7G^Efle@}~;CE4eAq(HܦUvGAUSl@+B, ̽)JJPLVlixX[uhS5[r.""n k3Z_gap:îJK-"dFc {.ƊScwh|m6MÜa#|$)(ӑen.(Ҫ!ilz,4 w;b{=PS:dղ0-"Ş+(nqquE]xy M".Fϔ>(`=_wUE,f& 2mC2-" z|לn57GKkkg ܘY[ %FIUT]W]YtV]sӸ6rqv!YgAuLL* *dŴk<ƅ[ O8ǂ]z?K I+^9SMqqj[%BEDTTIYQFfl7$6.d&"**.Xx,O+'-)JE)J>n{usmlvqpEpQQQy)")zQS~LW//۝$!pf K-(" Ԣ?ig$3q[UZE"%dlZX5.% *|#7P7QW s, 7Fr$b5P|6"+r%MrH8lYw%#f-@XrB""+IP 6=9JdVxXӹTψfM8&ݕ/4ڡ[O:.а ؏**+Tx/6]'úAsInDIm<.6h$EEEJVӜ17M"MbAif0(l‰6D*fH")ȉ0l EHvDOj-j{9t[a\Nd "I67^Qk.*m3B  q??H((R'.lu+ϓajlAp<(&UWaDMU1 O,CJΐlh_I+\Q7nc=iuzpQ9,ΉuOTtCk im$؄W§zCz]m[qwn.j7m S[ORRr&=[ڵ[I6o4iz~FFmC#Oz}!/q:m bmj웯wEDR@u8X'ך05afvL{=4o*]"juox[f@|yأ"˝j4ƮŖw) TTJᦼ SXd0Q,R#wq؂_ (jBrr※{ձ,:v` [nD!p v%EW.&Z$L5́opD&b*tI $S&Wq]M%:nVت'z )bnxŰ$Gm~=*8+mOze壘!~8ͭ+u3jt>!,˱ NM;tG>ȉYyl"yokKdGq+Q4XDCȁƉ U_&%oibܢ;k|xx!(|PeEPQQQ*!7NŽD̢[6n<h`F{9!UfFnvVF#rsjGZq/]DBٵ)#v|O+ݹSIF;HlA{LU 8r:AvS/ GrDF8o}[zHJ)% B(Hx7![*1I\5N(Al;4-OCn9:iJ3|]BuEJ"'sdmSfO!D|>&L""'dЗslØ+3varbY"BAmKӸ!,O{3-9&2E'Kwϒ)EJI y\ʹVzUԍUXy^.z~S?{_TX̱th1nfSpNnfF" |T𨜪g%.AL̅SsNAbOp[6$ozopi"R䦌GrcmE}oص)N掆 sj$rfW_(נ:dڙѕ;gzzc4D)^;~N?/ezdwi,8ˡe6ਐ*n<*/7KZuXz;: jT"'w2Ez 4Am>"&/WaZG>j_`-qct 8&|oc6 )9`:^bu3.5Bnn1SjԶpJO]mg(F9= #Ɔ@TD_?Q+OD^dMHҙ΁90 ʯW|"k?,lYb!ŘS URIU1N Pn )@+[19.@8H}%sR~S?{_S)ݿB#OzFoп ۄDR]UUWdDD(nǚK!"t].NU*Fv'cS?{_S)ݿBYڒ׋ ,KPy*<ЄQvQmR;m[߷#41蹼]dt訲E6sD]zuxyymeԷ HٳFFoпm7ϭErϣ{Mí% ] {uuQ{`||r.4+%9J*j`'U7eTET%rՅB[L%l:>r;vpHM2S⤛pU%*8@Nb .ȉnVvgŏQf[UaڜҤ"8$l m$삧tzʜ¤z%mLjB˨rw7<,x&@-vǓ[O5#")"Y'22aJfCF~OE򞪞Ƣd2sFnwoȒi؛RrQRE_zzөzmX:X$;,upjӻ4A֜'/[t/jx_l[b+'"KͲiAOU|%`j3w"o >}x4zw!DUT.5U5s=FYr+"r얗6p$VglWSzxp[6Th;g'S稅GԏȺ^5' g|ݿn~FϥhM/Ct1ql,{7.0YLi rFDP}+wDجd\l]ql 7NBH+*"jBm/-V `g[[<ֽDA7P6_i q8,de.ݭ=*,L5~6N;qQ?Z~S?{_Uyn7YHw.˰ϋ˳ u@HTDeZE(r=̮{)s o}noQ7~&\ܼᅳ9&\WsYǏHmTN/%7AN6fɮ dXUZL 9ˆ/5(bV_&ç6z"uu"981W4Q#uh5݌=i]bMɣ}MaA hFPm~88>/yQ';>bxYjL#siJ[ _KtfA짡i6* *rAİ;poKDFX7LmF7VUI>Iv>M$̆klvb?TZ:[ Q6]T܁󨬜KZcZ\3$ ·@j<*&ڐI4]ۑzwh{%58 qWUwFI8dk¢s-`M9ħ20.E3dJ+rmUT$>3%籴l֤= Ԍm4v6!B/^<%qS?{_T,h5# `($DDJH 4DI;3}˷mh LAn5@uO368;1Ǔ&伀d2ުF$DA@lO4[I@ Yd}OG?'r G?kIBO4k9BU#qloݦH)JDE5dM[UW_(cIObE?#p^|ʜxᅪɏ܇Q쭍BhƟ|M="IUbǏ"E.R6eL`l9n:4 H75-yl9Qyn6yfZ:d͖=r7 -]U=E]R׮ӥ9NmjNƒIm.-5&4/G}Bm<(|PKe&R/8|w9= ; M}F٧36 ƅ4 p 7BEOtvJP RTZ(Z퍘ݺ(BȢ(Wj( Ն꾡jbt͝3c3yQWYE+r{ԕPeO%zuJKljtzR("Kx?鞗S-6pT˒ݠoT%0F4rt1 e9mspUbMU? ҕa,, RRJ lx[m:lfpl7ʢ"5ݥ()J\‡)PDeжWes3Lv . >}{W-(⸟+m Fl؁EOD()JJRR f= h&vf\yQw.rsdےAu[[e`*h[ PMyKt=hzĈm&4뭊9ZYCURNBࠪ($-Ok%bN6*:Be[7wn8e> {-@,6d"JeU,pwQ NJiQT mxTV>j<,MjjX9Ae|qƝ]s3&g{6H$O <q Sj#˝Nk3!-I]@쓾ْ1(9+MIq].xVFcae`cpȅB*([*u2.l8] GByEAt_)|tuj4m[Olv}&V(,oybyб]K }B?-K(KoԴۙ#%n09%y#pHQ7R%UUWvmRCCZb@ej;a|HSǺ\Knfy*uzaw`\sޟ{ nNWI`Mi?=ٽi-O飫R3Im#*n+ǖjZkS"O\T+.-۞Tz}O2s[fw1Mj_u]|q Kr\E\HU-\)c5u2Hcxggp,[.ÂL=vˊ)mϲlW 7<~|ܑ=(G]oǝmLRĨB*/55~J<_[zYY珣8=kSnarrvO?iw.YYv,=0ߒ[HMB]Td|rƕ*No|L]jǙmz]>p3m}%ҭ]i2XxrŎbnx, 4Hd۠+D_ZRm7\ix"qAܿ">UKS/x!Ӳ鶞 *~R3&_y0AZlǚ 7  'vT1}цⶍf; ֚ D~jDJni@)JP R 4rL6$Mm v<⸟+J#F>c@N;/ojWew)@uٷ[㸎ǃObWQ+JP }WlG̢֗J[0PM2QiMT7TUVIJ ~*s)O[[msG cbJ<}.oՓVǺ쩪/fwñNSFj$6[R-;^t,۽R7#9c*,f ZS-ޠN4xu^"^ʳ‘=ߌb#oۖ/o㈌,%ɤeJ.6|;R从#Z;$kݴ^e$3'Ȏ[(:KQQS v)>Oq▉SbO4vB&ȅ&5T)JP R)@)JP R*gR<]l )>BNp%"PΐUu"prE! w]0El@II+gb?jpkWbX]xY̐;kN&N,I`ںx6QEp @odA1ܙθfFQdqEw5eZyߟ>VeJۃrwu#H3K>ZK@v9yv!TeK+gb?j6o'Hc.EO]\a%A}W;m49/HQ uLJ9ʛ.Ib]XR m 8/SbU!Jؾ- )RgDTxg.'w'N:NOrK$XQXli\UTTUO WHƅ?mKXmpyMxL>#tஃ|9lj@@--iT)r]/'uj5;up+` R)@)JP R)@)JP R)@)UèΪ/ƍ{7U_uxmø4H1-6D]mirJ },ZK_H9L#n@ \Y_̍nlkE2KK - 7V 8Ryeۗ_Xxuw D[*q)\dRSI`hM&b'Sg.7GX[ +: hM:I(6Pv={tVKciϤۻ 9b,%).U*X~y/B,ydu3* 3dŒ>`^.z < rs0}h ߯}v)@)JP R)@)JP RՖi!A&,;X> iH7vu[FKQL~v=يx9C~Mfr-HB'΀=`C+ٻ0x|\V]ӟhrwuWwD;Ï >Lvm;uŵA.%P<&W[X'ϩdKGziWpa]2rO'BLWG'qtlZQQcZӅ$s$X-&ɨ (,"9ā]1UҶKFc(~r,]z!ne_I&YՓq( !dfTo5kP32EDL߇ oy[UGQL>a9uamHKa\&~`&&MnD%WlӸdX26%zō-Zuq{%.N1UA+8#(z2ZR-.M!)+i7H}"zmHL l2+Us8smquc66*αMbIYi[~%|tN}UN,fnpB.l[ 0|ϧf)Knɹg 7vs,+ BH.M;kv+-&y2,clI$= _72wƑ#T&ՕjG#\$v~hqiP6Y7Ko;*"X|cD %5`IX #.*;xu Ed8ۂ$ 2h\jF*s2ЭrPi'tInD?z;|Wd\LK6Xʴ+"X0؋Ѥ 7ߘ˥ͳQB -wAE$uUcDQŖԈATK6ީ= Шr 9#1&ɱD/5D_KԁuG( . R-%G/[߾?&E6S+#-F۹8֟dn!Ōb8Jh날(b]U-/c.Eqo9Dzګܤd!5mW[DT=Ϭ7>g:eӲY.^ ky]R %Iu\Kg0! TE0U| \fbb:;C@M)>'S_H&o0eZ0*(%ʓiml]2RAj$N>#kȭ=?[x̸YFEМ&;.&@ ;hۈH$%"I,n_B-:;g%d) o2SF6 !ć䢂E[P'ZضYa"kc6^7#SZWd6"'QLI̹ 녳lQklF/pa̸#.k| 6 J`m4㟳s 4mm`#9!pEf惻DPK'15At}Y$ ےV۫QUlPQ"smʺqo{n;uYcgH)@C \&JRښ'Ϫ O˴IZTp^jhd8G]E/mF荶Sm"6FGP$a`0$ۮ6x%TXX4Ho]]kil5Ŕӎ R(}+(ɮX>i}xn7d $S,׽!Ah S֫c8ϗ"oәCBn#5dȐh $(ªq纸Rړ?Sdi=Ib4;ècFC$g);yV&سÖ56CiqHo ݣM:)xݧ)!;.u1eTbOeTu(@ a\=obTY௸OԵJ545A^m vf<-WH-n6M"*AUD%oYJP1QkIԗRo=x,\MF;Ͱ1I10+%P*ҀvNy/orȲD[1Æn1! z(\GUsQLmժ=8 Gseɸ>hl;'$q͹JXuً^nV-7 N)$O:Ҁ/Y=GS.7yWJ0d61 Ӑ䨁ű ._"ZY*fԮ+S.$tCT9 N6%E((hCw)BJg׭etQ!\O>n%ozlyQ6e&>%G5Er9fW"[r hy-՗Y&i]U*8!mq.qIkh>ظۨ.!l1!EEDT V8I{!X.A)DL@UZU 9r)JJRu)lXV 2:3Ij/6N*S +mSPRZ&՟Vi7))yiEvrHӢr&PtڗoEK%5ɸ2!jF78׉ ^>\ׇm4+JPJR)*07.]d{`nyD1T#UT[n`u;4jE]L4Xc$ܞ2qV|6Jj\-6GK,σC"e$^&;ĞS@T)}sjl+[ ?:sdC$VeFa%2UYF6qTuuɮRܺS݄3d st뺩ŴILinYCr۞qY)Ll+٨ +`TdjTKYxο4+)zd߇mMl4rH|cmlzLFY$[E LÛ68"h*l.ӥ+fu;:q -#I߃>R 6]SQ$ە()JJR(JPN(,& J*B"ʢW-)@)JP ,ŷG wMQ}Ri@)JP %$QJ7uP GVÌ\]Ro{xՇ휔uyr@4Ԧyw84 HHzpFNUoI̷DWm8*\Ymp=h+nCb@fUE[@UWdO Z(E~b؎%@n ˚Th.1L~ackVl48.$h]Ri_FQ*>Kť )&UgTwݱ}S&shI{S2`&28.`gU7ƺqG9)c뉸Q$[0 l\muGȿR9V}ArLK4ۼ\31bzy6!4=-܂8'h Sm['PKiNo'j#]/OB;bSpwM1t7qJT"cyd8xr )CQX<=QJPJRR()JJReXf[F͛llh$B$m%k0"W( Ԗc=-s\;= P{+e!SqPpŢle:XnI$ݱKKJSԅ<CWW!Gp۫؂zH( ^frxY-~^Γ_U%C&&)8$y%@B;Du[@,~$!QZ_{j"V m QQ䖖:5vO8+̣! ⃊c;#dJ;ZRR+G`r[fKg.oQ"IdɖvE^f;"R PuKncp9a?`EmpViy?ƪ[2p΀7&_ftM.Ei~AĹ#=l)8k]ktYRA /4hmH"B^B*W#";%h0$-:@mmoP&X7&{=|oiMt[UXH;^/3Xޛ^mN\ޓ%me#vj6)!"*֔$݊yWb