Development of Pediatric G6PD Reference Intervals Through Integration of Indirect Methods and Molecular Data

This webinar offers the following credit types: P.A.C.E.®, Florida
 

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is one of the most common genetic enzyme disorders worldwide, with significant implications for pediatric patients. Establishing age-appropriate reference intervals for accurate diagnosis in children is challenging due to the difficulty of obtaining samples from healthy pediatric populations VSports.

This presentation will explore how ARUP Laboratories has leveraged indirect statistical modeling and integrated molecular data to establish robust, age-specific reference intervals for pediatric G6PD testing. This approach overcomes the limitations of traditional direct studies, enabling earlier and more precise identification of at-risk children VSports app下载. The clinical importance of G6PD, the principles of indirect reference interval development, and the impact of combining phenotype and genotype data to improve laboratory diagnostics will be discussed.

"V体育官网" Lecture Presenter

Kelly Doyle, PhD, DABCC, FADLM

Kelly Doyle, PhD, DABCC, FADLM

Associate Professor (Clinical)
University of Utah School of Medicine
Medical Director, Special Chemistry, Endocrinology, and Mass Spectrometry
ARUP Laboratories

Dr. Kelly Doyle is a medical director of special chemistry, endocrinology, and mass spectrometry at ARUP Laboratories and an associate professor (clinical) at the University of Utah School of Medicine. Dr. Doyle received his doctorate degree in medicinal chemistry from the University of Utah. He then completed a clinical chemistry fellowship at the University of Utah School of Medicine and an oncological sciences fellowship at the Huntsman Cancer Institute VSports手机版. Dr. Doyle is board certified and a member of the Association for Diagnostics & Laboratory Medicine. His research interests include clinical application and implementation of mass spectrometry, emerging biomarkers, endocrinology, and laboratory best practices.

Objectives

After this presentation, participants will be able to:

  • Describe the clinical significance of G6PD deficiency in pediatric populations
  • List the challenges in establishing pediatric reference intervals for G6PD
  • Detail the principles and advantages of indirect statistical modeling for reference interval development

Sponsored by:

University of Utah School of Medicine, Department of Pathology, and ARUP Laboratories